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Title   폐암조직에서 Neuroendocrine Immunoperosidase Markers 의 발현 양상과 항암화학요법의 반응성에 관한 연구 ( Neuroendocrine Immunoperosidase Markers to Predict Chemotherapy Response in Lung Cancer Patients )
Publicationinfo   1993 Jan; 025(05): 664-673.
Key_word   Neuron specific enolase, Chromogranin A, Lung cancer
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Abstract   Some non-small cell lung cancer(NSCLC) express neuroendocrine(NE) characteristics, more typical of small cell lung cancer(SCLC). The present study examines the relationship between NE differentiation and chemotherapy response in lung cancer patients, retrospectively. We measured expression of immvnoperoxidase markers, neuron specific enolase(NSE) and chromogranin A(CHR), in bronchoscopic biopsied tumor tissues that were paraffin embedded sections. According to the result of chemotherpy response, all patients were categorized to responders(19 NSCLC, 12 SCLC)and nonresponders(16 NSCLC, 4 SCLC). We observed NSE and CHR marker expression more frequently in SCLC than in NSCLC, and in adenocarcinoma than in squamous cell type of NSCLC. Without regard to cancer cell type, the responders showed higher incidence of NSE and CBR marker expression and more prolonged median survival than the nonresponders. Also the patients with the expresion of either marker showed superior median survival(NSCLG 35.9 weeks, SCLC; 33.4 weeks) in comparison to the patients with the expression of neither marker(NSCLG 22.9 weeks, SCLC; 15.3 weeks)(NSCLC; p<0.05, SCLC; p<0.01). Our results suggest that the presence of NE differentiation is associated with a favorable chemotherapy response and a likelihood of survival prolongation.
저 자   정혁(Hyeok Jeong),이상재(Sang Jae Lee),박언섭(Weon Sub Park)